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2002;360:2333.,,,J,,,Acoust,,,Soc,,,Am.,,,A,,,,novel,,,,technique,,,,for,,,,inducing,,,,local,,,,inner,,,,ear,,,,damage.,,,,The,,,second,,,group,,,was,,,treated,,,with,,,vitamins,,,A,,,(2.1,,,mg/kg,,,beta-carotene,,,,p.o.),,,,C,,,(71.4,,,mg/kg,,,L-threoascorbic,,,acid,,,,s.c.),,,,and,,,E,,,(26,,,mg/kg,,,()-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic,,,acid,,,,“trolox”,,,,s.c.),,,(“ACE”,,,,N=8).,,,2005;208:1425..,,,

Miquel,,J,,,Economos,,AC,,,Fleming,,J,,,Johnson,,JE.,,,Jr,,Mitochondrial,,role,,in,,cell,,aging.,,Mitochodrial,,,,dysfunction,,,,and,,,,ROS,,,,production,,,,have,,,,been,,,,implicated,,,,in,,,,numerous,,,,neurodegenerative,,,,syndromes,,,,and,,,,diseases,,,,[28–34,,,,,see,,,,35,,,,,36].,,,,[PubMed]18.,,Alpha-tocopherol:,,,,Roles,,,,in,,,,prevention,,,,and,,,,therapy,,,,of,,,,human,,,,disease.,,,,ResultsNoise-induced,,,,threshold,,,,deficits,,,,were,,,,significantly,,,,smaller,,,,in,,,,animals,,,,treated,,,,with,,,,a,,,,combination,,,,of,,,,antioxidant,,,,agents,,,,and,,,,magnesium,,,,(see,,,,Figure,,,,1).,,,,[PubMed]51.,,[86],,confirmed,,that,,peak,,ROS,,and,,RNS,,production,,in,,cells,,in,,the,,organ,,of,,Corti,,occurs,,7–10,,days,,post-noise,,,and,,that,,noise-induced,,hair,,cell,,death,,is,,similarly,,delayed.,,2003;72:23692379.,,,2001;12:32993302.,,,Hawkins,,,JE.,,,,Jr,,,The,,,role,,,of,,,vasoconstriction,,,in,,,noise-induced,,,hearing,,,loss.,,,

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